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1999 1
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Upregulation of CD226 on subsets of T cells and NK cells is associated with upregulated adhesion molecules and cytotoxic factors in patients with tuberculosis.
Qin Y, Chen L, Fei Q, Shao X, Lv W, Yang J, Xu F, Shi J. Qin Y, et al. Int Immunopharmacol. 2023 Jul;120:110360. doi: 10.1016/j.intimp.2023.110360. Epub 2023 May 25. Int Immunopharmacol. 2023. PMID: 37244120
Here, we found that a subset of T cells and NK cells that constitutively express CD226 exhibit a distinct phenotype in TB patients. In fact, the proportions of CD226(+) and CD226(-) cell subsets differ between healthy people and tuberculosis patients, and the …
Here, we found that a subset of T cells and NK cells that constitutively express CD226 exhibit a distinct phenotype in TB patients. I …
Expression of human CD226 on T cells and natural killer cells and of soluble CD226 in plasma of HIV-1-infected Chinese patients.
Ye X, Zhang Z, Jiang Y, Han X, Wang Y, Zhang M, Liu J, Geng W, Dai D, Shi W, Shang H. Ye X, et al. Viral Immunol. 2006 Summer;19(3):576-81. doi: 10.1089/vim.2006.19.576. Viral Immunol. 2006. PMID: 16987076
Our objective was to detect the expression of CD226 on natural killer (NK) cells and T cells, and to measure the amount of soluble CD226 in the plasma of HIV-infected individuals, in order to evaluate the function of CD226 in HIV infection. ...We conclude tha …
Our objective was to detect the expression of CD226 on natural killer (NK) cells and T cells, and to measure the amount of soluble …
Expression of TSLC1 in patients with HAM/TSP.
Takenouchi N, Tanaka M, Sato T, Yao J, Fujisawa JI, Izumo S, Kubota R, Matsuura E. Takenouchi N, et al. J Neurovirol. 2020 Jun;26(3):404-414. doi: 10.1007/s13365-020-00838-z. Epub 2020 Apr 13. J Neurovirol. 2020. PMID: 32285300
Analysis of the Characteristics of TIGIT-Expressing CD3-CD56+NK Cells in Controlling Different Stages of HIV-1 Infection.
Zhang X, Lu X, Cheung AKL, Zhang Q, Liu Z, Li Z, Yuan L, Wang R, Liu Y, Tang B, Xia H, Wu H, Zhang T, Su B. Zhang X, et al. Front Immunol. 2021 Feb 26;12:602492. doi: 10.3389/fimmu.2021.602492. eCollection 2021. Front Immunol. 2021. PMID: 33717085 Free PMC article.
CD96 was significantly upregulated on NK cells after acute infection for 1 month and in chronic infection over 2 years, while CD226 was downregulated in chronic infection over 2 years. Further, at different stages of infection, CD96(-)CD226(+) cells diminished among …
CD96 was significantly upregulated on NK cells after acute infection for 1 month and in chronic infection over 2 years, while CD226 w …
Inverted CD8 T-Cell Exhaustion and Co-Stimulation Marker Balance Differentiate Aviremic HIV-2-Infected From Seronegative Individuals.
Scharf L, Pedersen CB, Johansson E, Lindman J, Olsen LR, Buggert M, Wilhelmson S, Månsson F, Esbjörnsson J, Biague A, Medstrand P, Norrgren H, Karlsson AC, Jansson M; SWEGUB CORE Group. Scharf L, et al. Front Immunol. 2021 Oct 12;12:744530. doi: 10.3389/fimmu.2021.744530. eCollection 2021. Front Immunol. 2021. PMID: 34712231 Free PMC article.
Unsupervised multidimensional clustering analysis identified a cluster of late differentiated CD8 T-cells expressing activation (CD38+, HLA-DR(int/high)), co-stimulatory (CD226+/-), and immune inhibitory (2B4+, PD-1(high), TIGIT(high)) markers that distinguished aviremic f …
Unsupervised multidimensional clustering analysis identified a cluster of late differentiated CD8 T-cells expressing activation (CD38+, HLA- …
Effect of aging on immune cells in male HIV-infected and -uninfected healthy individuals.
Rai MA, Shi V, Kennedy BD, Whitehead EJ, Justement JS, Paul S, Blazkova J, Chun TW. Rai MA, et al. AIDS. 2022 Nov 15;36(14):1935-1940. doi: 10.1097/QAD.0000000000003331. Epub 2022 Jul 16. AIDS. 2022. PMID: 35848591
OBJECTIVE: HIV induces immunologic dysfunction in T cells of infected individuals. However, the impact of aging on T cell phenotypes in HIV-infected individuals receiving antiretroviral therapy (ART) has not been fully delineated. ...METHODS: 110 HIV-infected aviremic male …
OBJECTIVE: HIV induces immunologic dysfunction in T cells of infected individuals. However, the impact of aging on T cell phenotypes …
Perturbed CD8(+) T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals.
Tauriainen J, Scharf L, Frederiksen J, Naji A, Ljunggren HG, Sönnerborg A, Lund O, Reyes-Terán G, Hecht FM, Deeks SG, Betts MR, Buggert M, Karlsson AC. Tauriainen J, et al. Sci Rep. 2017 Jan 13;7:40354. doi: 10.1038/srep40354. Sci Rep. 2017. PMID: 28084312 Free PMC article.
However, the extent to which the TIGIT/CD226/PVR-axis is affected by HIV-infection has not been characterized. ...These results depict a skewing of the TIGIT/CD226 axis from CD226 co-stimulation towards TIGIT-mediated inhibition of CD8(+) T cells, despite ear …
However, the extent to which the TIGIT/CD226/PVR-axis is affected by HIV-infection has not been characterized. ...These results depic …
'Emergency exit' of bone-marrow-resident CD34(+)DNAM-1(bright)CXCR4(+)-committed lymphoid precursors during chronic infection and inflammation.
Bozzano F, Marras F, Ascierto ML, Cantoni C, Cenderello G, Dentone C, Di Biagio A, Orofino G, Mantia E, Boni S, De Leo P, Picciotto A, Braido F, Antonini F, Wang E, Marincola F, Moretta L, De Maria A. Bozzano F, et al. Nat Commun. 2015 Oct 5;6:8109. doi: 10.1038/ncomms9109. Nat Commun. 2015. PMID: 26436997 Free PMC article.
Here, flow cytometric analysis of peripheral blood mononuclear cells in chronic inflammatory disorders, both infectious and non-infectious, reveals the presence of a CD34(+)CD226(DNAM-1)(bright)CXCR4(+) cell population displaying transcriptional signatures typical of commo …
Here, flow cytometric analysis of peripheral blood mononuclear cells in chronic inflammatory disorders, both infectious and non-infectious, …
Expression of the Inhibitory Receptor TIGIT Is Up-Regulated Specifically on NK Cells With CD226 Activating Receptor From HIV-Infected Individuals.
Yin X, Liu T, Wang Z, Ma M, Lei J, Zhang Z, Fu S, Fu Y, Hu Q, Ding H, Han X, Xu J, Shang H, Jiang Y. Yin X, et al. Front Immunol. 2018 Oct 10;9:2341. doi: 10.3389/fimmu.2018.02341. eCollection 2018. Front Immunol. 2018. PMID: 30364127 Free PMC article.
Additionally, levels of the TIGIT ligand, CD155, were higher on CD4(+) T cells from HIV-infected individuals compared with those from healthy controls; however, there was no difference in the level of the activating receptor, CD226, which recognizes the same ligands as TIG …
Additionally, levels of the TIGIT ligand, CD155, were higher on CD4(+) T cells from HIV-infected individuals compared with those from health …
Physical and functional association of LFA-1 with DNAM-1 adhesion molecule.
Shibuya K, Lanier LL, Phillips JH, Ochs HD, Shimizu K, Nakayama E, Nakauchi H, Shibuya A. Shibuya K, et al. Immunity. 1999 Nov;11(5):615-23. doi: 10.1016/s1074-7613(00)80136-3. Immunity. 1999. PMID: 10591186 Free article.
Whereas ligation of the DNAM-1 adhesion molecule triggers cytotoxicity mediated by normal NK and T cells, this function was defective in NK cell clones from leukocyte adhesion deficiency syndrome. However, genetic reconstitution of cell surface expression of LFA-1 restored …
Whereas ligation of the DNAM-1 adhesion molecule triggers cytotoxicity mediated by normal NK and T cells, this function was defective in NK …
14 results